Cerro Potosí, 3713 m altitude, located at , is the highest mountain in the Sierra Madre Oriental mountain range of northeast Mexico.
It is composed of limestone, and is noted for its very diverse flora including several endemic or near-endemic species, such as the Potosi Pinyon.
Access was very difficult in the past, but in the 1960s a microwave relay station was built on the summit, with the road built for this providing easy access from the east.